2023第七届公共卫生与医学科学国际会议

Dr. Zhaolan Liu, Professor

Center for Evidence-based Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China

Biography: Dr. Zhaolan Liu is a Professor in the Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese Medicine where she has been a faculty member since 2009. Dr. Zhaolan Liu completed her Ph.D. at Fudan University and her undergraduate studies at Shandong University. Her research interests lie in the area of Evidence-based Chinese medicine, ranging from theory to design to implementation.

Topic: The Methodological Framework of Target Trail Emulation and Its Application in Traditional Chinese Medicine

Abstract: Target trial emulation, using observational data to emulate a target trial, applies the study design principles of randomized trials to observational studies that aim to estimate the causal inference of intervention studies. The advantage of target trial emulation is that observational data is used to emulate a target trial when it is not appropriate to conduct randomized controlled trials. Target trial emulation can control bias caused by the design of observational studies, and improve the effectiveness of causal inference from observational data. This speech introduces the methodological framework and key methodological points for implementing target trial emulation, and analyzes the feasibility and advantages of the application of target trial emulation in the field of traditional Chinese medicine.

Dr. Ying Yang

The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China

Biography: Dr. Ying Yang is a researcher at State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University. Dr. Ying Yang is engaged in the inheritance, innovation, research and promotion of traditional medicine and traditional culture through multi-disciplines. The key research fields include liver disease diagnosis and treatment, food nutrition of herbs and emotional health. Dr. Ying Yang is the project leader of a number of national projects; she has published a number of high level articles of herbs and endogenous molecules on immune regulation and hepatitis B virus; she also has applied for patents of great economic and social value, which have been granted partly.

Topic: The Pharmaceutical Industry May Move into a New Industry of Medicinal and Edible Plants Under the Impact of COVID-19

Abstract: The Corona Virus Disease 2019 (COVID-19) global pandemic is characterized by a large number of people infected and multiple mutations of the virus; the sequelae of COVID-19 with more symptoms and longer duration affect multiple tissues and organs of the human body, with higher rates of anxiety, depression and other neurological problems happened 12 months after discharge from hospital, and with unknown mechanisms of fatigue and muscle weakness. These characteristics make it impossible for the pharmaceutical industry to develop drugs against targets, so it is necessary to seek effective therapies from traditional medicine. Chinese herbal medicine has long been a way for people to eat. Plant food with the same origin of medicine and food, regulates human balance and improves human self-healing ability. Plant food has high nutrition and improves human immunity. Adequate and balanced nutrition is essential for managing infections. The COVID-19 pandemic can lead to greater malnutrition, and studies have found that a plant-based diet for COVID-19 patients aged 65 or older during the pandemic reduces disease severity. Therefore, under the influence of COVID-19 for several years, the value of plant food nutrition in the prevention and control of diseases, especially large-scale infectious diseases, may be widely recognized, and the systemic change from the pharmaceutical industry to plant food nutrition may take place in the future.

Dr. Haitang Qiu, Associate Professor

The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Biography: Dr. Haitang Qiu is currently a doctor and researcher at The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. She received a Master's degree and a Ph.D. degree in Psychiatry in Chongqing Medical University in 2008 and 2020. She used to be a Visiting scholar of university of Pittsburgh. Now she is an Associate Professor, postgraduate tutor, National second-level psychological counselor; Director of Chongqing Mental Health Association; Vice Chairman of the Special Committee of Psychological Counseling and Treatment of Chongqing Mental Health Association; Project evaluation expert of Chongqing Ministry of Science and Technology. Her research interests include Adolescent mood disorder and suicidality. Over the past 5 years, Dr. Haitang Qiu has led one Youth National Natural Science Foundation of China and one Chong Qing Health Development Scientific Research Project, authored more than 10 peer-reviewed publications, and she has given many invited speeches at national conferences.

Topic: Understanding and Intervening the Current Situation of Depression and Suicidality in Chinese Adolescents

Abstract: Depression is prevalent, costly and a major cause of disability and death worldwide. The onset of depression often occurs early in life, during teen or young adult years. The onset of depression during adolescence is associated with increased risk for Major depression during adulthood, substance dependence, educational underachievement, unemployment, and early parenthood. The most severe consequence of untreated depression is suicide. Suicide is the 2nd leading cause of death among adolescents and has increased by 20% in the past decade. A school-based depression education program developed in 2010 by a team of psychiatrists and psychiatric nurses from The First Affiliated Hospital of Chongqing Medical University, has been implemented in 53 schools throughout the China of Chongqing with over 200,000 high school and university students. Screening for mental health problems in university and middle schools in China, and establishing a basic database of adolescent emotion and suicide information. The study found that depression and anxiety were the most common psychological problems reported by adolescents, and family satisfaction also had a direct impact on the emotional state of adolescents. Among adolescents who had committed suicide or self-harm, the scores of impulsivity and aggression were higher, which were important risk factors for suicide. The suicidality risk assessment model was established based on the mental health questionnaire information and other related information reported by the assessor. The model had a strong discrimination ability and good sensitivity and specificity. The model can provide hierarchical early warning for individuals and populations, and provide important reference for timely intervention. We further fitted the approximate relationship between the risk score of suicidality, and visually presented the approximate relationship as the risk level color scale in the way of gradual color scale for further individual and group warning. Based on the analysis of the mental health status of college students screened and the risk factors of college students with suicide attempts, a "medical-school-family joint mental illness and suicide prevention and intervention model" was established. Campus psychological services and family resources were integrated with local mental health institutions to ensure that students in need can receive timely, professional, targeted and personalized intervention. The rate of reported suicide attempts before intervention was 1.36% in the first year and 0.98% in the second year. Rates of reported suicide attempts have decreased.

Dr. Pingping Zhu, Professor

School of Life Sciences, Zhengzhou University, Zhengzhou, China

Biography: Dr. Pingping Zhu got his Ph.D. certificate of Biochemistry and Molecular Biology in 2016, as a joint-training student in the University of Science and Technology of China (USTC) and the Institute of Biophysics, Chinese Academy of Sciences (IBP, CAS). He focused on adult stem cells (ASCs), cancer stem cells (CSCs) and Organoid, and identified several critical modulators in CSC self-renewal. He has published in Several papers in Nat Immunol, Neuron, Nat Cell Biol, Nat Struct Mol Biol, J Clin Invest and Nat Communs.

Topic: Screening and Functional Study of Early Biomarkers of Liver Cancer

Abstract: Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths across the world. Due to the lack of reliable markers for early HCC detection, most HCC patients are diagnosed in middle/late stages. Liver cancer stem cells (CSCs), which are drivers of liver tumorigenesis, usually emerge in the early HCC stage and are also termed as liver tumor initiation cells (TIC). Liver CSCs contribute to initiation, propagation, and metastasis of HCC and also play a key role in tumor therapy. Taking advantage of online-available data sets, bioinformatic analyses, and experimental confirmation, here we have screened out PRC1 and RACGAP1 as reliable markers for early HCC detection. PRC1 or RACGAP1 knockdown dramatically inhibited the proliferation, migration, and invasion capacities of HCC cells, conferring PRC1 and RACGAP1 as predominant modulators for HCC propagation and metastasis. Moreover, the sphere formation capacity of HCC cells was impaired after PRC1 knockdown, revealing the function of PRC1 as a modulator for liver CSC self-renewal. Furthermore, the inhibitor of PRC1 had same phenotypes as PRC1 knockdown in HCC cells. Altogether, PRC1 and RACGAP1 are identified both as prognosis markers for early HCC detection and therapeutic targets for liver cancer and liver CSCs, adding additional layers for the early prognosis and therapy of HCC.